You will need malaria prophylaxis and strong mosquito repellent. It is also not a bad idea to treat your clothes with permethrin, which is available from most camping stores. A mosquito net is probably optional as almost all accommodation in Zanzibar will provide one.
If you go to the infectious diseases clinic at your home hospital they can also give you the most up to date advice on what other vaccinations (ie Hep B, yellow fever, cholera) and drugs (ie HIV post exposure kit) you need.
When in Zanzibar you will need to boil tap water if you wish to drink it. Alternatively, bottled water can be purchased just about anywhere and is not too expensive.
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